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KMID : 0043320180410020243
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Archives of Pharmacal Research
2018 Volume.41 No. 2 p.243 ~ p.250
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Anti-inflammatory effects of sinapic acid on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice
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Lee Ji-Yun
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Abstract
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This study was conducted to evaluate the effect of sinapic acid, a cinnamic acid derivative, on inflammatory changes in a mouse model of colitis. Colitis was induced by intracolonic instillation of 2,4,6-trinitrobenzenesulfonic acid (TNBS). Sinapic acid (10, 30, and 100 mg/kg) and dexamethasone (2 mg/kg) were orally administered to Balb/c female mice after TNBS instillation. The anti-inflammatory effect of sinapic acid on colonic injury or damage was assessed by clinical, macroscopic, microscopic, and biochemical analyses. Compared with TNBS control, treatment with sinapic acid significantly improved colonic weight and length and decreased the macroscopic and microscopic changes in TNBS-induced colitis. Furthermore, myeloperoxidase activity and the colonic tissue levels of malondialdehyde and tumor necrosis factor alpha were decreased by administration of sinapic acid. The findings of this study suggest that sinapic acid exerts anti-inflammatory effects on intestinal inflammation and can be selected as a novel therapeutic candidate in the treatment of inflammatory bowel disease.
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KEYWORD
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Sinapic acid, 2, 4, 6-Trinitrobenzenesulfonic acid, Colitis, Myeloperoxidase, Malondialdehyde, TNF-α
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